1) (an) opinion, explanation or criticism in speech or writing about an event, book, state of affairs etc (comment)

2) (the belief in) a political and social system which maintains an established state of affairs without great or sudden change (conservatism)

3) a piece of work; employment; a fortunate state of affairs (job)

4) a position (of a town, building etc); a condition, state of affairs especially at a certain time; a job; employment (situation)

5) to untie, unfasten, loosen (knots, buttons etc); to destroy (something good) and bring back the (bad) state of affairs that existed before (undo)